Dat Trieu                                                                                                                            

Project Engineer

Dat has over 20 years experience in pharmaceutical engineering, validation and technical services.   He is innovative, energetic and possesses strong technical and leadership skills. He has a broad background and extensive knowledge of solid dose pharmaceutical technology.  

EXPERIENCE…

• Hands on experience with development and validation of fluid bed coating of pellets/tablets/granules, roller compaction, high shear granulation, hydrogel, and wax-matrix tablets.
• Performed IQ/OQ/PQ of various equipment including fluid bed coaters, tab coaters, tablet presses, granulators, encapsulators, tank/mixers, ovens, packaging lines, and support utilities
• Responsible for initiation, development and management of a validation department at a pharmaceutical manufacturing organization that successfully validated all equipment, utilities and facilities of a 250,000 sq. ft. production facility and a 100,000 sq. ft. warehouse.
• Key member of the management team that developed a new pharmaceutical operation from a start-up to the 5th fastest growing domestic company in 2000.
• Started and built a technical services department that successfully scaled up and validated several complex, controlled release solid dose products.
• Led inter-departmental product launch teams for a pharmaceutical manufacturing facility.
• Managed and provided hands on support of team that was responsible for scale up, optimization and validation of controlled release solids dose processes.
• Transferred and validated solids dose product and processes to worldwide subsidiaries and licensees.
• Performed trouble shooting and optimized existing product and processes.   Solved poor dose uniformity of potent, low dose tablets.   Developed and validated power end point for high shear granulation.
• Specified, purchased and validated required production equipment.
• Developed and scaled up controlled released (microencapsulation) formulation and processes.
• Supervised operation of esterification production operation.
• Perfromed bench scale optimization and start-up of bulk chemical processes

POSITIONS HELD…

• Project Engineer                                                             BioTeknica
• Director, Validation                                                         Andrx Pharmaceuticals, Inc.
• Sr. Engineer/Group Leader, Tech. Services                  Upsher-Smith Laboratory      
• Sr. Project Engineer, Engineering & Tech. Services      Merck & Company    
• Formulation Specialist                                                    Monsanto Company
• Production Supervisor                                                    Monsanto Company
• Sr. Research Engineer                                                   Monsanto Company

EDUCATION…

• M.S. Chemical Engineering                                            Washington University
• B.E. Chemical Engineering (Magna cum Laude)           Vanderbilt University

PRESENTATION…

• Instructor:                        Validation of Solids Dosage Processes, Parental Drug Association

PATENTS…

• EU Patent No. 83870143.1

Two-stage Crystallization of Nitrolotriacetonitrile , February 1, 1984

• U.S. Patent No. 4,485,049
  Two-stage Crystallization of Nitrolotriacetonitrile from a Hot Solution, November 27, 1984 Three Patent Disclosures